The epigenetic regulation of autonomous replicons

The epigenetic regulation of autonomous replicons

Blog Article

The discovery of autonomous replicating sequences (ARSs) in Saccharomyces cerevisiae in 1979 was considered a milestone in unraveling the regulation of replication in eukaryotic cells.However, shortly afterwards it became obvious that in Saccharomyces 9-Piece Dining Set pombe and all other higher organisms ARSs were not sufficient to initiate independent replication.Understanding the mechanisms of replication is a major challenge in modern cell biology and is also a prerequisite to Coat developing application-oriented autonomous replicons for gene therapeutic treatments.This review will focus on the development of non-viral episomal vectors, their use in gene therapeutic applications and our current knowledge about their epigenetic regulation.